Endocrine Abstracts

Bilateral adrenalectomy usually results in lifelong primary adrenal insufficiency. Evidence exists that up to 34% of patients with Cushing’s disease (CD) have some degree of endogenous cortisol secretion after bilateral adrenalectomy due to ACTH driven hyperplasia of residual cortical tissue. We present a case of a patient with atypical corticotropinoma/carcinoma and recurrence of CD after bilateral adrenalectomy.A 59-year-old man presented with Cus...

Introduction: Falsely elevated serum chromogranin A (CgA) is associated with the use of proton pump inhibitors, the presence of renal impairment and systemic inflammation. We aimed to investigate which laboratory parameters are independently associated with increased CgA and to develop a nomogram, in order to improve the diagnostic accuracy of CgA in detecting patients with neuroendocrine tumors (NET).Methods: Our retrospective study included 155 subject...

Intrathyroidally located parathyroid carcinoma is extremely rare cause of primary hyperparathyroidism. Multifocal papillary and follicular thyroid carcinomas are rather common.We report a case of 40-year old man presenting with substantial weight loss, anemia and multiple osteolytic lesions of both tibias. Peak serum calcium level was 5.0 mmol/l, parathyroid hormone (PTH) level was 989 pg/ml. Left thyroid lobe was firm and enlarged. Routine percutaneous ...

Studies that consolidate the results of medicamentous and surgical treatment of pituitary adenomas are scarce. Pure endoscopic endonasal transsphenoidal surgery is rather new technique.The aim of this study is to report on early postoperative outcome of pure endoscopic endonasal transsphenoidal surgery and to present the results of multimodal treatment in patients with postsurgical failure.We reviewed 117 consecutive patients who u...

Aims: Diabetic ketosis (DK) and diabetic ketoacidosis (DKA) are known complications of type 1 diabetes mellitus (T1DM). However, DK and DKA have been described in T2DM. Referred to as ketosis-prone T2DM, this subtype of T2DM has been described in Hispanics and Afro-Americans of sub-Saharan Africa, but the incidence and pathogenesis remains unknown. We aimed to analyze characteristics of patients with diabetic ketosis (DK) and diabetic ketoacidosis (DKA) in Ca...

Introduction: Little is known about diabetic ketoacidosis (DKA) in type 2 diabetes mellitus (T2DM). Moreover, the clinical impact of diabetic ketosis (DK) in T2DM is elusive. The aim of this study was to analyze characteristics and mortality of patients with DKA and DK and to identify possible prognostic factors.Methods: This was a population-based, cross-sectional study that included all patients with T2DM presenting to emergency department with DKA, ov...